![](https://images.squarespace-cdn.com/content/v1/61e5b3b5bb3de93bd4872009/1642533877034-RGB78KUUIBULX4NH9JRW/Screen%2BShot%2B2022-01-18%2Bat%2B2.21.45%2BPM.jpg)
Effects of Inactivation of VTA DA Projections to the mPFC on Functional Connectivity, Motivation, and Reinforcement Based Learning
UNC-CH NSCI 423: Developing Neurotechnology
Take a look at samples from our research presentation below!
⇩
Course research presentation for NSCI 423: Developing Neurotechnology (Course-based Undergraduate Research Experience Class) @ UNC; presented by Azlan Khan, Hannah Henderson, Jessica Harvey, Parker Jenkins
Research thesis: Inactivating the ventral tegmental area (VTA) to medial prefrontal cortext (mPFC) neural pathway will cause a decrease in activation and functional connectivity of the nucleus accumbens (NAc), thereby decreasing in motivation and reinforcement-based learning in macaque models.
As a part of NSCI 423 at UNC-CH, we looked at developing neurotechnologies, the evolution of research and research methodology in the field of neuroscience, and new budding techniques for research within this field.
For this culmination of semester-long research, we were tasked with analyzing a chosen paper using a neurotechnological methodology of interest, and to craft a follow-up experimental design and hypothesis to extend the reaches of our analyzed paper. My group and I chose to look at selective messoaccumbal pathways and subsequent effects on functional connectivity, motivation, and reinforcement-based learning in macaque models (you can read the original paper here). As a follow-up experiment, we hypothesized that inactivating the ventral tegmental area (VTA) to medial prefrontal cortext (mPFC) neural pathway will cause a decrease in activation and functional connectivity of the nucleus accumbens (NAc), thereby decreasing in motivation and reinforcement-based learning in macaque models.
![Screen Shot 2022-01-18 at 2.22.01 PM.png](https://images.squarespace-cdn.com/content/v1/61e5b3b5bb3de93bd4872009/f7172cf9-911b-4f64-8eb6-07ef8da5a388/Screen+Shot+2022-01-18+at+2.22.01+PM.png)
![Screen Shot 2022-01-18 at 2.22.08 PM.png](https://images.squarespace-cdn.com/content/v1/61e5b3b5bb3de93bd4872009/4591565d-be89-4f72-a790-5960d74a3225/Screen+Shot+2022-01-18+at+2.22.08+PM.png)
![Screen Shot 2022-01-18 at 2.22.18 PM.png](https://images.squarespace-cdn.com/content/v1/61e5b3b5bb3de93bd4872009/0186611e-cae9-4bd3-8c29-b1415c06eede/Screen+Shot+2022-01-18+at+2.22.18+PM.png)